genomic DNA - определение. Что такое genomic DNA
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Что (кто) такое genomic DNA - определение

CHROMOSOMAL DNA, IN CONTRAST TO EXTRA-CHROMOSOMAL DNAS LIKE PLASMIDS
Gdna; GDNA
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Comparative genomic hybridization         
  • ACGH profile of the IMR32 neuroblastoma cell line
  • Figure 2. Array-CGH protocol
METHOD TO EVALUATE BIOLOGICAL SAMPLES
Comparative genomic hybridization (CGH); Array-comparative genomic hybridization; ACGH; Array CGH; Comparative Genomic Hybridization; Comparative Genomic Hybridisation; Comparative hybridization; Array comparative genomic hybridisation; Cot 1 DNA; Cot-1 DNA; Comparative genome hybridization; Chromosomal microarray analysis; CGH array; Array comparative genomic hybridization; Array-comparative Genomic Hybridization; Microarray-based comparative genomic hybridization; A-CGH; Array hybridization
Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome).
Genomic island         
PART OF A GENOME THAT HAS EVIDENCE OF HORIZONTAL ORIGINS
Genomic islands; Genetic island
A genomic island (GI) is part of a genome that has evidence of horizontal origins. The term is usually used in microbiology, especially with regard to bacteria.
DNA glycosylase         
  • 
Hydrolysis of cytosine to uracil
ENZYMES INVOLVED IN BASE EXCISION REPAIR
GO system; Dna glycosylases; Dna glycosylase; DNA glycosylases; Dna Glycosylase
DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.
DNA bank         
STORAGE OF PHYSICAL DNA SAMPLES
Dna bank; DNA Bank
DNA banking is the secure, long term storage of an individual’s genetic material. DNA is most commonly extracted from blood, but can also be obtained from saliva and other tissues.
DNA supercoil         
  • Supercoiled structure of circular DNA molecules with low writhe. The helical nature of the DNA duplex is omitted for clarity.
  • Figure showing the various conformational changes which are observed in circular DNA at different pH.  At a pH of about 12 (alkaline), there is a dip in the sedimentation coefficient, followed by a relentless increase up to a pH of about 13, at which pH the structure converts into the mysterious "Form IV".
  • Stochastic, prokaryotic model of the dynamics of RNA production and transcription locking at the promoter region, due to PSB.
  • Drawing showing the difference between a circular DNA chromosome (a plasmid) with a secondary helical twist only, and one containing an additional tertiary superhelical twist superimposed on the secondary helical winding.
  • Supercoiled structure of linear DNA molecules with constrained ends. The helical nature of the DNA duplex is omitted for clarity.
  • Illustration of how cold shock affects the supercoiling state of the DNA, by blocking the activity of Gyrase. The signs ‘ − ’ and ‘+’ represent negative and positive supercoiling, respectively. Created with BioRender.com. Also shown is a stochastic model of gene expression during cold shock as a function of the global DNA supercoiling state. The transition from ON to OFF of the promoter (P) causes the locking of transcription (i.e. RNA production). When ON, the promoter can produce RNA, from which proteins can be produced. RNA and proteins are always subject to degradation or dilution due to cell division.
COMPRESSED DNA LOOP SUPERCOILED BY PROKARYOTES TO FIT WITHIN A SMALL SPACE
Supercoil; Supercoiling; Dna, circular; Supercoiling of DNA; Positive supercoiling; Twist (DNA); Writhe (DNA); Supercoiled; Superhelical DNA energetics; Surface wrapping of DNA; DNA supercoiling; Circular genome; Supercoiled DNA; Superhelical DNA; Supertwisted DNA; Plectonemic supercoil; Linking number of DNA; Negative supercoiling; Superhelical dna
DNA supercoiling refers to the amount of twist in a particular DNA strand, which determines the amount of strain on it. A given strand may be "positively supercoiled" or "negatively supercoiled" (more or less tightly wound).
DNA sequencing         
  • Genomic DNA is fragmented into random pieces and cloned as a bacterial library. DNA from individual bacterial clones is sequenced and the sequence is assembled by using overlapping DNA regions.
  • sequencing of proteins]], and the other for the sequencing of DNA.
  •  Sequencing of the TAGGCT template with IonTorrent, PacBioRS and GridION
  • The 5,386 bp genome of [[bacteriophage φX174]]. Each coloured block represents a gene.
  • NHGRI]].
  • doi-access = free}}</ref>
  • An Illumina HiSeq 2500 sequencer
  • An Illumina MiSeq sequencer
  • Illumina NovaSeq 6000 flow cell
  • Library preparation for the SOLiD platform
  • A BGI MGISEQ-2000RS sequencer
  • Multiple, fragmented sequence reads must be assembled together on the basis of their overlapping areas.
  • An example of the results of automated chain-termination DNA sequencing.
  • Two-base encoding scheme. In two-base encoding, each unique pair of bases on the 3' end of the probe is assigned one out of four possible colors. For example, "AA" is assigned to blue, "AC" is assigned to green, and so on for all 16 unique pairs. During sequencing, each base in the template is sequenced twice, and the resulting data are decoded according to this scheme.
TECHNIQUE IN MOLECULAR BIOLOGY
Dideoxy sequencing; Gene sequencer; Dye terminator sequencing; Dna sequencing; DNA Sequencing; Genomic sequencing; Automated DNA sequencing; Sequencing technology; High-throughput sequencing; Big Dye Terminator; Working draft dna sequence; Finished dna sequence; DNA sampling; Genome Sequencer; Sanger DNA Sequencing; DNA sequence; High throughput sequencing; Next generation sequencing; Single-molecule sequencing; Sequencing Technologies; Base sequence analysis; Next Generation Sequencing; Sequencing DNA; Next gen sequencing; Next-gen sequencing; Sequencing genomes; Sequencing technologies; Abandoned DNA; QTL sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine.
Ancient DNA         
  • 50px
  • Map of human fossils with an age of at least ~40,000 years that yielded genome-wide data<ref name="zlaty"/>
DNA ISOLATED FROM ANCIENT SPECIMENS
Fossil DNA; Paleo DNA; Ancient DNA analysis; Ancient DNA revolution; Ancient genomes; Paleogenome; Palaeogenome
Ancient DNA (aDNA) is DNA isolated from ancient specimens. Due to degradation processes (including cross-linking, deamination and fragmentation) ancient DNA is more degraded in comparison with contemporary genetic material.
DNA database         
DATABASE OF DNA PROFILES
National DNA database; National DNA Database; DNA databank; Dna databanking; DNA Database; Genetic Database; National dna database; Dna database; DNA databases; Forensic DNA database; Genetic genealogy database; Medical DNA database; DNA Index System; Genetic database
A DNA database or DNA databank is a database of DNA profiles which can be used in the analysis of genetic diseases, genetic fingerprinting for criminology, or genetic genealogy. DNA databases may be public or private, the largest ones being national DNA databases.
DNA profiling         
  • Sir [[Alec Jeffreys]], pioneer of DNA profiling. His discovery led to the conviction of [[Colin Pitchfork]] in 1988.<ref name="Eureka"/>
  • CBP]] chemist reads a DNA profile to determine the origin of a commodity.
  • Restriction Fragment Length Polymorphism
  • issue=2}}</ref>
TECHNIQUE USED TO IDENTIFY AN INDIVIDUAL ON THE BASIS OF THEIR DNA CHARACTERISTICS
Genetic fingerprint; DNA fingerprinting; DNA fingerprint; Forensic DNA; Forensic genetics; Tommie Lee Andrews; DNA Fingerprinting; DNA profile; DNA evidence; Fingerprinting dna; Fingerprinting DNA; Dna fingerprinting; Dna matching; DNA Analysis; DNA fingerprints; DNA Profiling; Familial searching; Genetic fingerprinting; Dna Fingerprinting; DNA identification; Genetic Fingerprinting; Familial DNA; Fake DNA evidence; DNA recognition; DNA siblingship testing; Core STR profile; DNA screening
DNA profiling (also called DNA fingerprinting) is the process of determining an individual's DNA characteristics. DNA analysis intended to identify a species, rather than an individual, is called DNA barcoding.
DNA fingerprinting         
  • Sir [[Alec Jeffreys]], pioneer of DNA profiling. His discovery led to the conviction of [[Colin Pitchfork]] in 1988.<ref name="Eureka"/>
  • CBP]] chemist reads a DNA profile to determine the origin of a commodity.
  • Restriction Fragment Length Polymorphism
  • issue=2}}</ref>
TECHNIQUE USED TO IDENTIFY AN INDIVIDUAL ON THE BASIS OF THEIR DNA CHARACTERISTICS
Genetic fingerprint; DNA fingerprinting; DNA fingerprint; Forensic DNA; Forensic genetics; Tommie Lee Andrews; DNA Fingerprinting; DNA profile; DNA evidence; Fingerprinting dna; Fingerprinting DNA; Dna fingerprinting; Dna matching; DNA Analysis; DNA fingerprints; DNA Profiling; Familial searching; Genetic fingerprinting; Dna Fingerprinting; DNA identification; Genetic Fingerprinting; Familial DNA; Fake DNA evidence; DNA recognition; DNA siblingship testing; Core STR profile; DNA screening
DNA fingerprinting is the same as genetic fingerprinting
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Википедия

Genomic DNA

Genomic deoxyribonucleic acid (abbreviated as gDNA) is chromosomal DNA, in contrast to extra-chromosomal DNAs like plasmids. Most organisms have the same genomic DNA in every cell; however, only certain genes are active in each cell to allow for cell function and differentiation within the body.

The genome of an organism (encoded by the genomic DNA) is the (biological) information of heredity which is passed from one generation of organism to the next. That genome is transcribed to produce various RNAs, which are necessary for the function of the organism. Precursor mRNA (pre-mRNA) is transcribed by RNA polymerase II in the nucleus. pre-mRNA is then processed by splicing to remove introns, leaving the exons in the mature messenger RNA (mRNA). Additional processing includes the addition of a 5' cap and a poly(A) tail to the pre-mRNA. The mature mRNA may then be transported to the cytosol and translated by the ribosome into a protein. Other types of RNA include ribosomal RNA (rRNA) and transfer RNA (tRNA). These types are transcribed by RNA polymerase I and RNA polymerase III, respectively, and are essential for protein synthesis. However 5s rRNA is the only rRNA which is transcribed by RNA Polymerase III.